Central-acting agents lower your heart rate and reduce your blood pressure. They work by preventing your brain from sending signals to your nervous system to speed up your heart rate and narrow your blood vessels. As a result, your heart doesn't pump as hard and your blood flows more easily through your blood vessels.
Examples of central-acting agents
Central-acting agents are also called central adrenergic inhibitors, central alpha agonists and central agonists. Several central-acting agents are available. Which one is best for you depends on your health and the condition being treated.
Examples of central-acting agents include:
- Clonidine (Catapres)
- Guanfacine (Tenex)
Uses for central-acting agents
Doctors prescribe central-acting agents to prevent, treat or improve symptoms in conditions, such as:
- High blood pressure
- Hot flashes
- Alcohol or drug withdrawal
- Attention-deficit/hyperactivity disorder (ADHD)
- Tourette syndrome
Side effects and cautions
These medications can have strong side effects, so they aren't commonly used. Side effects include:
- Extreme fatigue
- Drowsiness or sedation
- Dry mouth
- Weight gain
- Psychological problems, such as depression
Abruptly stopping use of some central-acting agents can cause a sudden, dangerous increase in blood pressure. Don't stop taking these medications, especially if you are taking a beta blocker, without talking to your doctor.