Mayo Clinic Health Library

HPV test

Updated: 05-15-2012

Definition

The human papillomavirus (HPV) test detects the presence of human papillomavirus, a virus that can lead to the development of genital warts, abnormal cervical cells or cervical cancer.

Your doctor might recommend the HPV test if:

  • Your Pap test was abnormal, showing atypical squamous cells of undetermined significance (ASCUS)
  • You're age 30 or older

The HPV test is available only to women; no HPV test yet exists to detect the virus in men. However, men can be infected with HPV and pass the virus along to their sex partners.

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Why it's done

The HPV test is a screening test for cervical cancer, but the test doesn't tell you whether you have cancer. Instead, the test detects the presence of HPV, the virus that causes cervical cancer, in your system. Certain types of HPV — including types 16 and 18 — increase your cervical cancer risk.

Knowing whether you have a type of HPV that puts you at high risk of cervical cancer means that you and your doctor can better decide on the next steps in your health care. Those steps might include follow-up monitoring, further testing, or treatment of abnormal or precancerous cells.

Routine use of the HPV test in women under age 30 isn't recommended, nor is it very helpful. HPV spreads through sexual contact and is very common in young women, so, frequently, the test results will be positive. But HPV infections often clear on their own within a year or two. Cervical changes that lead to cancer take several years — often 10 years or more — to develop. For these reasons, you might follow a course of watchful waiting instead of undergoing treatment for cervical changes resulting from an HPV infection.

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Risks

As with any screening test, an HPV test carries the risk of false-positive or false-negative results.

  • False-positive. A false-positive test result indicates that you have a high-risk type of HPV when you really don't. A false-positive result could lead to an unnecessary follow-up procedure, such as colposcopy or biopsy, and undue anxiety over the test results.
  • False-negative. A false-negative test result means you really do have an HPV infection, but the test indicates that you don't. This might cause a delay in appropriate follow-up tests or procedures.
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How you prepare

No special preparation is necessary before you have an HPV test. However, since an HPV test often is done at the same time as a Pap test, you can take these measures to make both tests as accurate as possible:

  • Avoid intercourse, douching, or using any vaginal medicines or spermicidal foams, creams or jellies for two days before the test.
  • Try not to schedule the test during your menstrual period. The test can be done, but your doctor can collect a better sample of cells at another time in your cycle.
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What you can expect

An HPV test is usually done at the same time as a Pap test — a test that collects cells from your cervix to check for abnormalities or the presence of cancer. An HPV test can be done using the same sample from the Pap test or by collecting a second sample from the cervical canal.

During the HPV test
A combination Pap-HPV test is performed in your doctor's office and takes only a few minutes. You may be asked to undress completely or only from the waist down.

You'll lie on your back on an exam table with your knees bent. Your heels rest in supports called stirrups.

Your doctor will gently insert an instrument called a speculum into your vagina. The speculum holds the walls of the vagina apart so that your doctor can easily see your cervix. Inserting the speculum may cause a sensation of pressure in your pelvic area. Sometimes the speculum feels cold when it's first inserted.

Then your doctor will take samples of your cervical cells using a soft brush and a flat scraping device called a spatula. This doesn't hurt, and you may not even feel the sample being taken.

After the HPV test
After your test, you can go about your normal daily activities without any restrictions. Ask your doctor about when you can expect to receive your test results.

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Results

Results from your HPV test will come back as either positive or negative.

  • Positive HPV test. A positive test result means that you have a type of HPV that's linked to cervical cancer. It doesn't mean that you have cervical cancer now, but it's a warning sign that cervical cancer could develop in the future. Your doctor will probably recommend a follow-up test in six months to a year to see if the infection has cleared or to check for signs of cervical cancer.
  • Negative HPV test. A negative test result means that you don't have any of the types of HPV that cause cervical cancer.

Depending on your test results, your doctor may recommend one of the following as a next step:

  • Normal monitoring. If you're over age 30, your HPV test is negative and your Pap test normal, you'll follow the generally recommended schedule for repeat testing in three years.
  • Colposcopy. In this follow-up procedure, your doctor uses a special magnifying lens (colposcope) to more closely examine your cervix.
  • Biopsy. In this procedure, sometimes done in conjunction with colposcopy, your doctor takes a sample of cervical cells (biopsy) to be examined more closely under a microscope.
  • Removal of abnormal cervical cells. To prevent abnormal cells from developing into cancerous cells, your doctor may suggest a procedure to remove the areas of tissue that contain the abnormal cells.
  • Seeing a specialist. If your Pap test or HPV test results are abnormal, your health care provider will probably refer you to a gynecologist for a colposcopic exam. If test results show that you might have cancer, you may be referred to a doctor who specializes in treating cancers of the female genital tract (gynecologic oncologist) for treatment.
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