Researchers have evaluated a variety of natural products for effectiveness against chronic fatigue syndrome. Most results have been disappointing.
A few remedies — magnesium injected into the muscles for people with low red blood cell magnesium, a combination of fish oil and evening primrose oil, melatonin, NADH, propionyl-L-carnitine, and D-ribose — have shown encouraging results in preliminary studies. However, many of these promising early results weren't confirmed by follow-up studies, or the original studies were too small to be conclusive.
At this time, there's little evidence to recommend any specific natural remedy as a treatment for chronic fatigue.