Mayo Clinic Health Library

Ectopic pregnancy

Updated: 02-09-2012

Definition

Pregnancy begins with a fertilized egg. Normally, the fertilized egg attaches itself to the lining of the uterus. With an ectopic pregnancy, the fertilized egg implants somewhere outside the uterus.

An ectopic pregnancy typically occurs in one of the tubes that carry eggs from the ovaries to the uterus (fallopian tubes). This type of ectopic pregnancy is known as a tubal pregnancy. In some cases, however, an ectopic pregnancy occurs in the abdominal cavity, ovary or neck of the uterus (cervix).

An ectopic pregnancy can't proceed normally. The fertilized egg can't survive, and the growing tissue might destroy various maternal structures. Left untreated, life-threatening blood loss is possible. Early treatment of an ectopic pregnancy can help preserve the chance for future healthy pregnancies.

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Symptoms

At first, an ectopic pregnancy might not cause any signs or symptoms. In other cases, early signs and symptoms of an ectopic pregnancy might be the same as those of any pregnancy — a missed period, breast tenderness and nausea. If you take a pregnancy test, the result will be positive. Still, an ectopic pregnancy can't continue as normal.

Abdominal or pelvic pain and light vaginal bleeding are often the first warning signs of an ectopic pregnancy. If blood leaks from the fallopian tube, it's also possible to feel shoulder pain or an urge to have a bowel movement — depending on where the blood pools or which nerves are irritated. Heavy vaginal bleeding is unlikely, unless the ectopic pregnancy occurs in the cervix.

If the fallopian tube ruptures, heavy bleeding inside the abdomen is likely — followed by lightheadedness, fainting and shock.

When to see a doctor
Seek emergency medical help if you experience any signs or symptoms of an ectopic pregnancy, including:

  • Severe abdominal or pelvic pain accompanied by vaginal bleeding
  • Extreme lightheadedness or fainting
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Causes

A tubal pregnancy — the most common type of ectopic pregnancy — happens when a fertilized egg gets stuck on its way to the uterus, often because the fallopian tube is inflamed, damaged or misshapen. Hormonal imbalances or abnormal fetal development might also play a role. Sometimes, the specific cause of an ectopic pregnancy remains a mystery.

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Risk factors

Up to an estimated 20 in every 1,000 pregnancies are ectopic. Various factors are associated with ectopic pregnancy, including:

  • Previous ectopic pregnancy. If you've had one ectopic pregnancy, you're more likely to have another.
  • Inflammation or infection. Inflammation of the fallopian tube (salpingitis) or an infection of the uterus, fallopian tubes or ovaries (pelvic inflammatory disease) increases the risk of ectopic pregnancy. Often, these infections are caused by gonorrhea or chlamydia.
  • Fertility issues. Some research suggests an association between difficulties with fertility — as well as use of fertility drugs — and ectopic pregnancy.
  • Structural concerns. An ectopic pregnancy is more likely if you have an unusually shaped fallopian tube or the fallopian tube was damaged, possibly during surgery. Even surgery to reconstruct the fallopian tube can increase the risk of ectopic pregnancy.
  • Contraceptive choice. With proper use, pregnancy when using an intrauterine device (IUD) is rare. If pregnancy occurs, however, it's more likely to be ectopic. The same goes for pregnancy after tubal ligation — a permanent method of birth control commonly known as "having your tubes tied." Although pregnancy after tubal ligation is rare, if it happens it's more likely to be ectopic.
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Complications

When you have an ectopic pregnancy, the stakes are high. Without treatment, a ruptured fallopian tube could lead to life-threatening bleeding.

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Preparing for your appointment

Seek emergency medical help if you develop any signs or symptoms of an ectopic pregnancy, including:

  • Severe abdominal or pelvic pain accompanied by vaginal bleeding
  • Extreme lightheadedness or fainting

If you have possible signs or symptoms of ectopic pregnancy — such as light vaginal bleeding or abdominal pain — contact your doctor. He or she might recommend an office visit or immediate medical care. Here's some information to help you prepare, as well as what to expect from your doctor.

What you can do
Ask a loved one or friend to be with you, if possible. Sometimes it can be difficult to remember all of the information provided, especially in an emergency situation. If you can, it's also helpful to jot down your questions ahead of time. Here are some basic questions you might want to ask your doctor:

  • What kinds of tests do I need?
  • If the pregnancy isn't located in my uterus, where is it?
  • What are the treatment options?
  • What are my chances of having a healthy pregnancy in the future?
  • How long should I wait before trying to become pregnant again?
  • Will I need to follow any special precautions if I become pregnant again?

In addition to your prepared questions, don't hesitate to ask questions anytime you don't understand something.

What to expect from your doctor
Your doctor is likely to ask you a number of questions. For example:

  • When was your last period?
  • Did you notice anything unusual about your last period?
  • Could you be pregnant?
  • Have you taken a pregnancy test? If so, was the test positive?
  • Are you in pain?
  • Are you bleeding? If so, how heavily are you bleeding?
  • Are you experiencing any lightheadedness or dizziness?
  • Have you been pregnant in the past? If so, what was the outcome?
  • Have you had any reproductive surgery, including any that involved your fallopian tubes?
  • Have you been diagnosed with any sexually transmitted infections?
  • Have you had in vitro fertilization?
  • What form of birth control do you use, if any?
  • Do you plan to become pregnant in the future?
  • Are you being treated for any other medical conditions?
  • Are you taking any medications?
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Tests and diagnosis

If your doctor suspects an ectopic pregnancy, he or she might do a pelvic exam to check for pain, tenderness, or a mass in the fallopian tube or ovary. A physical exam alone usually isn't enough to diagnose an ectopic pregnancy, however. The diagnosis is typically confirmed with blood tests and imaging studies, such as an ultrasound.

With a standard ultrasound, high-frequency sound waves are directed at the tissues in the abdominal area. During early pregnancy, however, the uterus and fallopian tubes are closer to the vagina than to the abdominal surface. The ultrasound will likely be done through a wand-like device placed in your vagina.

Sometimes it's too soon to detect a pregnancy through ultrasound. If the diagnosis is in question, your doctor might monitor your condition with blood tests until the ectopic pregnancy can be confirmed or ruled out through ultrasound — usually by four to five weeks after conception.

In an emergency situation — if you're bleeding heavily, for example — an ectopic pregnancy might be diagnosed and treated surgically.

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Treatments and drugs

A fertilized egg can't develop normally outside the uterus. To prevent life-threatening complications, the ectopic tissue must be removed.

If the ectopic pregnancy is detected early, an injection of the drug methotrexate is sometimes used to stop cell growth and dissolve existing cells. After the injection, your doctor will monitor your blood for the pregnancy hormone human chorionic gonadotropin (HCG). If the HCG level remains high, you might need another injection of methotrexate.

In other cases, ectopic pregnancy is treated with laparoscopic surgery. In this procedure, a small incision is made in the abdomen, near or in the navel. Then your doctor uses a thin tube equipped with a camera lens and light (laparoscope) to view the area. Other instruments can be inserted into the tube or through other small incisions to remove the ectopic tissue and repair the fallopian tube. If the fallopian tube is significantly damaged, it might need to be removed.

If the ectopic pregnancy is causing heavy bleeding or the fallopian tube has ruptured, you might need emergency surgery through an abdominal incision (laparotomy). In some cases, the fallopian tube can be repaired. Typically, however, a ruptured tube must be removed.

In a few cases, an injection of methotrexate is needed after surgery.

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Prevention

You can't prevent an ectopic pregnancy, but you can decrease certain risk factors. For example, limit your number of sexual partners and use a condom when you have sex to help prevent sexually transmitted infections and reduce the risk of pelvic inflammatory disease.

If you've had an ectopic pregnancy, talk to your doctor before conceiving again. When you become pregnant, your doctor will carefully monitor your condition. Early blood tests and ultrasound imaging can offer the earliest detection of another ectopic pregnancy — or reassurance that the pregnancy is developing normally.

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Coping and support

Losing a pregnancy is devastating, even if you've only known about it for a few days. Recognize the loss, and give yourself time to grieve. Talk about your feelings and allow yourself to experience them fully. Rely on your partner, loved ones and friends for support. You might also seek the help of a support group, grief counselor or other mental health provider.

Most women who have ectopic pregnancies go on to have other, healthy pregnancies. If one fallopian tube was injured or removed, an egg might be fertilized in the other tube before entering the uterus. If both fallopian tubes were injured or removed, in vitro fertilization might be an option. With this procedure, mature eggs are fertilized in a lab and then implanted into the uterus.

If you choose to conceive again, seek your doctor's advice. Early blood tests and ultrasound imaging can offer prompt detection of another ectopic pregnancy — or reassurance that the pregnancy is developing normally.

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