| Study Name |
Physician
Investigator |
Dates |
Evaluated |
| 6944 ICD Lead |
Ip |
1998-2001 |
A phase I study of new Medtronic ICD lead |
| A COMET1/A STAR |
Ip |
2000-2002 |
To assess efficacy of daily oral azim2HCI vs placebo in treating or preventing Afib |
| ABCD |
Ip |
2001-2003 |
A prospective multi-center study to determine the effectiveness of TWA in predicting VT events in patients with ischemic disease and NSVT |
| Ablate |
Gandhi |
2009-2012 |
Atrial fibrillation ablation catheters |
| ACT |
Ip |
2005-2008 |
BiV ICD registry |
| Act I/Scene II |
Ip |
2003-2004 |
A placebo controlled study of RSD 1235 in subjects with Afib or Aflutter |
| Act II |
Ip |
2004 |
A placebo controlled study of RSD 1235 in subjects with Afib or Aflutter in p CABG |
| Act III |
Ip |
2004-2007 |
A placebo controlled study of RSD 1235 in subjects with Afib or Aflutter |
| Act IV |
Ip |
2005-2007 |
Open label study of RSD 1235 in subjects with Afib or Aflutter |
| Act V |
Ip |
2009-2011 |
Drug for new onset Afib |
| ACUITY |
Cohn |
2004-2007 |
A study of Angiomax vs. heparin in PCI for ACS w/o ST seg elevation |
| ACUTE II |
Markarian |
1997-2002 |
A randomized trial to investigate a TEE guided approach to anti-coagulation management to decrease incidence of embolization after cardioversion |
| Admire HF |
Melvin |
2005-2009 |
Eval of I123mibg sintigraphy in assessing myocardial sympathetic innervation in subjects with heart failure |
ADOPT A
High enrolling site |
Ip |
1998-2002 |
A randomized trial to evaluate new pacemaker algorithm for over-drive pacing for prevention of Afib |
| Aegis Model 2600 |
Thakur |
1996-1998 |
A study of the safety and efficacy of the Aegis Model 2600 |
| AF CHF |
Ip |
2001-2007 |
To compare therapeutic strategy to restore and maintain sinus rhythm in patients with CHF and AF vs. a strategy of rate control alone |
| Amiodarone Aqueous I.V. |
Cheng |
2000-2002 |
A comparison of the incidence of hypotension with 2 formulations of IV Amiodarone: Cordarone IV vs. Aqueous Amiodarone IV injection |
| AMIOVIRT |
Thakur |
1997-2002 |
A randomized trial for patients with NSVT and non-ischemic myopathy randomized to Amiodarone or ICD |
| APL Poly |
Thakur |
2005-2007 |
A study of the Siteline 2 pacemaker lead |
| APLAUD |
D'Haem |
1997-2000 |
A study to assess safety, tolerability, pharmacokinetics & effect on platelet aggrefation of a dose range of SB 214857 with aspirin in patients with MI, unstable angina, TIA or stoke |
| Appraise 2 |
Wilcox |
2009-2011 |
Drug addon for ACS |
| Aristotle |
Ip |
2007-2011 |
New drug vs. Warfarin in patients with Afib |
| ARRIVE 2 |
D'Haem |
2005-2008 |
A registry for Taxus drug eluting stents |
| ASCEND HF |
James |
2007-2008 |
A study of Nesteritide in Decompensated Heart Failure |
| ASPIRE2 |
Cohn |
1997-2003 |
To evaluate the safety and efficacy of renal artery stenting compared to balloon angioplasty alone |
| Assess AF |
Ip |
2011 |
Post market study of loop recorder monitoring of Afib post ablation |
| ASSESS HF |
James |
2005-2006 |
A study of CHF physician use of Carelink data |
| ASSURE |
Cheng |
2001-2002 |
To diagnose recurrent, unexplained syncope using the Reveal Plus ILR compared with conventional strategies |
| Astaxanthin |
Helble |
2000-2002 |
Astaxanthin supplementation and potential reduction of C-reactive protein levels |
| AVE S7 Stent Registry |
Sharif |
2002-2003 |
A post market study of Medtronic AVE S7 with discrete technology coronary stent |
| AWARE |
Ip |
2005-2006 |
Analysis of AT/AF detection in dual chamber pmkrs |
| BH88 |
Strobl |
1999-2000 |
To test the Ensure diagnostic concept for predicting an individual's cholesterol responsiveness to diet therapy. |
| Bradycare |
Thakur |
2010-2012 |
Post market pacemaker study |
| Bravo |
D'Haem |
1999-2002 |
A study to compare the incidence of clinical events in patients receiving lotrafiban or placebo combined w/aspirin |
| Cadillac |
D'Haem |
1997-2001 |
To compare clinical outcomes between the ACS RX Multilink stent to ptca when used within 12 hours of acute MI |
| Capture 2 |
Cohn |
2006-2009 |
Carotid stent registry |
| Champion PCI |
Cohn |
2006-2009 |
Drug vs. clopidogrel in PCI |
| Champion Platform |
Cohn |
2006-2009 |
Drug vs. clopidogrel in PCI |
| CHARM |
James |
1999-2003 |
Candesartan in Heart Failure-Assessment of reduction in mortality and morbidity |
| Choice |
Cohn |
2009-2012 |
Carotid Stent Registry |
| Clear |
Ip |
2007-2011 |
Study of pacemaker rate changes |
| COMMA |
D'Haem |
2001-2002 |
A trial of two IV dosing regimens of h5G1.1-scFv in patients with acute MI undergoing PTCA |
| Cook Balloon |
Berkompas |
1998-1999 |
A study of the new MBC balloon dilatation catheters |
| Copernicus |
James |
1998-2001 |
A trial to determine the effect of carvedilol on mortality in patients with severe chronic heart failure |
| Corinthian |
Cohn |
1999-2001 |
To evaluate the safety and effectiveness of the Cordis Palmaz Corinthian stent in iliac patients after suboptimal PTA |
| CoStar II |
Cho |
2005-2011 |
Conor DES vs. Taxus |
| CPI Pace/Sense Acute Study Device |
Ip |
1995-1997 |
A study of the pacing & sensing capabilities of PS-ASD devices |
| CRAFT Highest enroll US |
Ip |
2001-2002 |
A trial of the tolerance & efficacy of RSD1235 in patients with recent onset Afib |
| CREDO |
D'Haem |
1999-2002 |
A double-blind randomized trial of clopidogrel & aspirin for the prevention of vascular events and mortality in patients undergoing coronary intervention |
| CRUSADE |
Sharif |
2002-2003 |
A QI study of risk stratification of unstable angina to suppress adverse outcomes with early implementation of ACC/AHA guidelines |
| Current/Promote Automaticity |
Ip |
2008-2010 |
New features in ICDs & BiV ICDs |
| Dal Outcomes |
Wilcox |
2009-2012 |
Drug for recent ACS |
| DeCode |
Thakur |
2007-2008 |
A study of home monitoring of BP, weight and BiV ICD |
| DeFeat PE |
Ip |
2009-2012 |
Detect fluid early from intra thoracic impedance monitoring |
| DEFINITE |
Thakur |
2000-2003 |
Defibrillators in non-ischemic cardiomyopathy treatment evaluation |
| DIARY |
Thakur |
2004-2005 |
A study of CHF events in patients with BiV ICDs |
DTI-0009
Highest Enrolling |
Cheng |
2001 |
Outpatient intravenous drug for treatment of narrow QRS complex tachycardia or atrial fibrillation/flutter |
| DTI-0009 Phase 2 |
Cheng |
2001-2002 |
A randomized, dose response trial of IV DTI-0009 for ventricular rate control in adult patients with Afib |
| EARLY ACS |
D'Haem |
2004-2007 |
A study of eptifibatide in non ST elevation ACS |
| EGM Width |
Ip |
1997-1999 |
A evaluation of changes in EGM width over time and with changes in body position |
| ENPULSE |
Ip |
2003-2004 |
An evaluation of the accuracy of the atrial capture management feature and overall system performance of the Enpulse series pacemaker |
| Epic II PAS |
Ip |
2006-2007 |
A study of patient notifier feature of ICD |
| ESP Registry |
James |
2008-2011 |
Registry of heart failure patients |
| ESSENTIAL |
James |
2001-2005 |
A trial of oral Enoximone vs. placebo in advanced chronic heart failure subjects |
| EZ Path |
Strobl |
2006-2007 |
Exetimibe added to statin in high risk subjects |
| Freedom |
Castellani |
2006-2009 |
AV op echo vs. Quick op for BiV ICDs |
| FSR |
Ip |
2006-2007 |
Study of new pacemaker lead |
| FUSION II |
James |
2004-2007 |
A study comparing serial Natecor infusions vs. placebo for Class III & IV CHF |
| GAMMA |
Ip |
2005-2007 |
Study of new drug for ventricular tachycardia |
| HAT |
Ip |
2002-2007 |
A study of the use of home AED vs. CPR |
| Hestia |
Ip |
2010-2012 |
Drug for Afib |
| High Frequency Stimulation |
Ip |
1997-2000 |
To determine if high frequency stimulation induced cardioversion is possible by prolonging the afib cycle lengths in patients w/persistent Afib treated w/propfanone |
| ICD Septal Lead |
Ip |
1999-2001 |
A study to show if defibrillation thresholds can be reduced by placing the RV coil along the interventricular septum |
| IMPACT |
Strobl |
2002 |
A study of the impact of medical specialty on patient compliance to treatment |
| INSYNC Registry |
Ip |
2002-2011 |
A post market study of InSync devices |
| Internal Cardioversion |
Ip |
1997-2000 |
A study of intracardiac defibrillation in patients with Afib who failed conventional transthoracic cardioversion |
| ITI Iliac Stent |
Berkompas |
1999-2005 |
A randomized trial of Intratherapeutic's iliac stent for iliac artery occlusion/Suboptimal angioplasty |
| IV Amiodarone |
Ip |
1993-2000 |
An open label safety study of Intravenous Amiodarone HCI in patients with life threatening ventricular tachycardia/fibrillation |
| JUMBO |
Berkompas |
2003-2004 |
A study to evaluate a new oral antiplatelet agent in PCI with stent |
| LINK |
Ip |
2006-2008 |
Study of new ICD lead |
| MBG313 |
Melvin |
2005-2009 |
Follow up study for patients enrolled in Admire HF |
| MedHall Outcomes |
Fabaz |
2000-2003 |
Influence of prosthetic valve type and orientation on clinical and hemodynamic outcome after aortic valve replacement |
| Microny/Regency |
Ip |
1997-2001 |
To evaluate the safety and efficacy of the Microny SR+ & Regency SR+ pacemakers when used in combination with Tendril DX or passive plus DX leads |
| MIST |
Cohn |
2000-2001 |
A comparison of two stents in de novo or restenotic iliac arteries with suboptimal PTA |
| Model 1242T & 1246T Endocardial Pacing Leads |
Thakur |
1995-1997 |
A study of Pacesetter passive plus bipolar, endocardial pacing leads |
| Model 7218 ICD |
Thakur |
1995-1999 |
A study of the safety & effectiveness of Medtronic Model SPI system used in the detection & treatment of VT & VF |
| Models 7217B & 7219E PCDs with Endotak 60 |
Ip |
1994-1996 |
A study of the safety and effectiveness of ENDOTAK 60 series lead system (JEWEL) in detecting & treating VT & VF |
| MUSTT |
Ip |
1993-1998 |
Multicenter Unsustained Tachycardia Trial |
| NAPA |
Holden |
2005-2006 |
Study of Natrecor in CABG |
| Napa 3 |
Collar |
2006-2007 |
Alfimeprase in acute peripheral arterial occlusion |
| Natural Hx of Afib Highest Enrolling |
Ip |
2000-2003 |
A prospective, randomized, parallel group, single blinded study of patients w/Afib, no cardioversion and a need for a dual chamber pacemaker |
| Navi Star Thermo Cool |
Cheng |
2001-2003 |
Evaluation of the Navi Star Thermo Cool Catheter w/Stockert 70 radiofrequency generator for endocardial ablation in patients w/a flutter |
| Octave |
Strobl |
2000-2002 |
A comparison of omapatrilat vs. enalapril for hypertension |
| OM8 |
Ip |
2007-2009 |
A study of drug for Afib |
| Open Label Carvedilol |
James |
2000-2001 |
A open label study of Carvedilol in patients that participated in the Copernicus study |
| OPTION |
Ip |
2004-2007 |
A study of the Biotronik biventricular ICD |
| OPUS 1 |
D'Haem |
1996-2000 |
A study to compare clinical restenois rates, quality of life & costs in patients treated with "optimal" PTCA with stent only when necessary vs. routine stent use |
| OriginEP |
Cheng |
2000-2001 |
A study to assess the practical feasibility of the noninvasive OriginEP multi-electrode ECG mapping system in recording single beats |
| PAIRED |
Ip |
2005-2007 |
Paroxysmal Afib Incidence Reporting with Early Detection Study |
| PAS |
Ip |
2005-2009 |
A registry for St. Jude BiV ICDs |
| Pascal |
Ip |
2006-2008 |
New drug vs. placebo in patients with paroxysmal AF and pacemaker with AF data logging capabilities |
| Plato |
Cohn |
2007-2009 |
Drug vs. clopidogrel in ACS |
| PREVENT IV |
Roth |
2002-2005 |
A Phase III study to compare CGT003 (an EF2 decoy) to placebo in CABG patients to inhibit neointima formation to prevent atherosclerosis in vein grafts |
| Prevent V |
Duda |
2004-2005 |
A study of E2F Decoy in hemodialysis grafts |
| PRIMO CABG |
Holden |
2002-2003 |
A trial of Pexelizumab total mortality & MI in patients undergoing CABG |
| PRIMO CABG II |
Holden |
2004-2006 |
A study of drug vs. placebo for patients undergoing CABG |
| Prince |
Strobl |
2000-2002 |
A study of the effect of pravastatin on plasma levels of C reactive protein (hs-CRP) in primary and secondary prevention |
| Promote Q |
Ip |
2009-2012 |
Study of new ICD lead |
| Prophylaxis w/Sotalol |
Ip |
1996-1998 |
A study to evaluate the efficacy of Sotalol in preventing post operative Afib/Aflutter in the cardiac surgery patient. It also assessed the SAECG as a predictor |
| PROTEGE |
Berkompas |
2001-2006 |
A trial of the protege self expanding nitinol stent in iliac artery disease |
| Protocol 24 |
Strobl |
2006-2007 |
Study of statin with niacin |
| PROVE |
Ip |
2005-2007 |
Programming VT therapy in ICD |
| PROVE-IT |
Strobl |
2000-2003 |
A double-blind, randomized trial for patients who have experienced an acute coronary syndrome to compare two statin drugs and examine the role of infection |
| Provide |
Ip |
2009-2011 |
Study of ICD programming for primary prevention to prolong time to first shock |
| PURSUIT |
D'Haem |
1996-2002 |
A study of 2 dosing regimens of Integrelin vs. placebo for reducing mortality & MI in patients with unstable angina or Non Q wave MI |
| Quickflex |
Ip |
2008-2010 |
New ICD pacing lead |
| Red Cabg |
Collar |
2009-2010 |
Drug used in CABG |
| RED HF |
James |
2006-2007 |
Darbepoetin for anemia in CHF |
| REOMI |
D'Haem |
1997-2002 |
A study of the effect of Glycoprotien 11b/111a inhibition without thrombolytic therapy on reperfusion in acute MI |
| Replace |
Cohn |
2000-2004 |
A study of angiomax in percutaneous coronary intervention to reduce clinical events |
| REPLACE2 |
Cohn |
2001-2003 |
A study of angiomax in percutaneous coronary intervention to reduce clinical events |
| Response HF |
Ip |
2005-2007 |
Response of Cardiac Resynchronization Therapy w/V-V timing for St. Jude BiV ICDs |
| RESTORE |
Berkompas |
2001-2005 |
To demonstrate the ITI renal stent is safe & effective for treating renovascular htn caused by renal artery stenosis or occlusion |
| RESTORE IT |
Collar |
2006-2007 |
A study of antibiotic for carotid stenosis |
| Retavase |
Veenendaal |
1997-1998 |
A study of prehospital use of the thrombolytic Retavase |
| RETHINQ |
Ip |
2005-2007 |
Study of narrow QRS in CRT Therapy |
| Revive |
Berkompas |
1998-2000 |
A non-randomized evaluation of the ACS multi-link duet coronary stent system in saphenous vein grafts |
| RHYTHM |
Ip |
2002-2005 |
Resynchronization for Hemodynamic Treatment for Heart Failure Management |
RID-AF
Highest enrolling |
Ip |
1999-2002 |
A study to show reduced incidence & duration of AF/AT with the Jewel AF Dual Chamber AMD |
| Rocket AF |
Ip |
2008-2010 |
Drug vs. Warfarin for Afib |
| RVA vs. RVOT |
Ip |
2000-2002 |
A comparison of exercise capacity in patients with pacing leads in the right ventricular apex vs. the right ventricular outflow tract |
| SAFARI |
Ip |
2002-2007 |
A study to evaluate the safety & efficacy of the Selection Model 9000 application in patients who are currently indicated for a dual chamber pacemaker |
SCDHeFT
Highest enrolling |
Ip |
1998-2003 |
A randomized study of effectiveness of Amiodarone (or placebo) vs. defibrillator in reducing SCD in HF |
| Scdheft 10 yr. |
Ip |
2010-2012 |
Ten year followup on original Scdheft subjects |
| SOAR |
Cohn |
1999-2003 |
A non-randomized, prospective, multi-center, consecutive registry of sub-optimal renal angioplasty |
| SPIDER |
Berkompas |
2004-2005 |
A study of the Spider distal protection device for PCI in SVG |
| Spirit IV |
D'Haem |
2006-2012 |
New drug eluting stent |
| Sponge |
Collar |
2007-2009 |
Antibiotic sponge to prevent cardiac sternal wound infections |
STAMINA HFP
Enrolled Maximum |
James |
2002-2003 |
A multi-center, prospective, observational heart failure study |
| STELLAR |
D'Haem |
2003-2006 |
A registry for Cypher drug eluting stents |
| Subpectoral Implantation of ICD |
Ip |
1992-1997 |
A study of a non-epicardial ICD using transvenous lead & submuscular patch in life threatening arrthythmias |
| Sudden Cardiac Death Athletic Screening |
Cheng |
2000-2002 |
Can a hospital based screening program identify athletes at risk for sudden cardiac death |
| Suport |
Berkompas |
1999-2002 |
A study to compare Scimed NIR stent vs. ACS Multilink Duet |
| SYMPHONY |
D'Haem |
1997-2001 |
An aspirin controlled trial to evaluate sibrafiban, an oral platelet glycoprotein 11b/111a antagonist, as therapy for the prevention of secondary vascular events in ACS |
| SYNERGY |
D'Haem |
2001-2004 |
A trial to compare low molecular weight heparin, enoxaparin vs. unfractionated heparin in high risk patients with non ST elevation acute coronary syndromes |
| Tendril DX Endocardial lead |
Thakur |
1995-2000 |
A study of the safety & efficacy of the Tendril DX model 1388T steroid eluting screw in pacing lead |
| TOVA |
Thakur |
2000-2003 |
Study of ICD patients to gain insight into triggering of potentially lethal arrthymias |
| TP 10 |
Collar |
2000-2002 |
A phase II study to address the negative effects of complement activation during and following coronary artery bypass surgery |
| TP10-002 |
Collar |
2004-2006 |
A study of TP10 in women undergoing CABG |
| TRIAGE |
Ip |
2006-2008 |
A study of home monitoring of BP, weight & BiV ICD |
| Trilogy DR+ Models 2360L & 2364L |
Thakur |
1995-1996 |
A study to evaluate the operation,k safety & efficacy of the Trilogy DR+ pulse generator in patients requiring dual chamber, rate responsive pacemakers for bradycardia |
| Trilogy SR+ Models 2260L & 2264L |
Thakur |
1995-1997 |
A study to evaluate the Trilogy SR+ pulse generator in patients requiring an implanted, single chamber, rate responsive pacemaker for bradycardia |
| TRUMPET |
Strobl |
1998-1999 |
A phase IV study of the lipid changes in patients treated with Tricor |
| TRUST |
Ip |
2005-2009 |
Study of wireless home monitoring of ICD |
| Ultra Revive |
Berkompas |
1999-2001 |
A study of the ACS Multi Link Ultra coronary stent in patients with saphenous graft & de novo native lesions |
| VALIANT |
D'Haem |
1998-2003 |
A comparison of efficacy & safety of long term treatment with valsartan, catopril & their combination in high risk patients after MI |
| VALOR |
Markarian |
2002-2004 |
A study comparing the renal effects of Visipague vs. Optiray for creatinine levels in subjects undergoing coronary angiography/PCI |
| VASCUCOIL |
Cohn |
1997-2003 |
To clinical investigation of the Vascucoil self expanding peripheral stent |
| Vascular Wrap |
Duda |
2007-2010 |
Drug infused wrap for vascular graft access |
| Ventak Prx III HC AICD |
Thakur |
1995-1996 |
A study of the safety & efficacy of a Ventak PRx with the pulse generator can being an active electrode (hot can) vs. non-active can (cold can) |
| VIBRANT |
Ip |
2003-2006 |
A registry study of Vitatron dual chamber pacemakers. |
| VICTORY |
Ip |
2005-2007 |
Study of autocapture in dual chamber pacemaker |
| VIGOR SR |
Thakur |
1994-1995 |
A study of the safety and efficacy of the CPI single chamber VIGOR SR pulse generator, Models 1130 & 1135 & the associated software module Model 2075 |
| WCD |
Ip |
2000-2001 |
Study of the safety and effectiveness of the Wearable Cardioverter Device in transplant, complicated post MI and complicated coronary bypass patients |
| Women take Pride |
Strobl |
1999-2003 |
Effects of Heart Disease Education on Older Women |