Crest 2 |
The main purpose of the study is to find out if the incidence of stroke or death is different or the same between subjects that receive medical management alone compared to subjects that receive medical management in combination with carotid endarterectomy (CEA) or carotid artery stenting (CAS). |
Heart & Vascular |
Carotid Stenosis |
ESsCAPE |
The main objective of the trial is to assess the efficacy and safety of the drug trimodulin as adjunctive treatment to standard of care compared to placebo plus standard of care in adults hospitalized with severe community-acquired pneumonia on invasive mechanical ventilation. |
Pulmonary |
Respiratory |
COG-AALL1331 |
Risk Stratified Randomized Phase lll Testing of blinatumomab (IND#117467, NCS#765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL) |
Childhood Cancers |
Leukemia |
Real AF |
Real-world Experience of Catheter Ablation for the Treatment of Symptomatic Paroxysmal and Persistent Atrial Fibrillation Using Novel Contact Force Technologies: REAL AF Registry |
Heart & Vascular |
Atrial Fibrillation |
COG-AALL05B1 |
Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens |
Childhood Cancers |
Leukemia |
COG-ACNS0831 |
Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years |
Childhood Cancers |
Glioma |
COG:ACNS1123 |
Phase 2 trial of response based radiation therapy for patients with localized central nervous system Germ Cel Tumors |
Childhood Cancers |
Tumor |
COG: ARST1321 |
Pazopanib Neoadjuvant triao in Non-Rhabdomyosarcoma soft tissue sarcomas(PAZNTIS): A phase II/III randomized trial preoperative chemoradiation or preop radiation plus or minus Pazopanib |
Childhood Cancers |
Sarcoma |
Amulet |
Patients will have nonvalvular atrial fibrillation. This irregular beating of the heart leads to a slowing of the blood flow in the upper chambers of the heart. In the left upper chamber, there is a small pouch called the left atrial appendage (LAA). Slowing of blood, especially in the LAA, may cause blood clots to form. Blood clots can move from the LAA and travel to the brain, causing a stroke or transient ischemic attack (TIA), also called a mini-stroke. These blood clots can also travel to other parts of the body and block blood vessels. The Amulet device could be beneficial because it may lower the chance of a new blood clot forming and moving from the heart’s LAA to other parts of your body. |
Heart & Vascular |
Structural Heart Disease |
Node X |
Participants must have participated in a prior study with the investigational drug etripamil (the NODE-301, NODE-302, or NODE-303 study). The study is being done to determine the safety of etripamil 70 mg for the treatment of multiple episodes of PSVT in an at-home setting. |
Heart & Vascular |
Cardiac Arrhythmia |
COG-ANBL00B1 |
Neuroblastoma Biology Studies |
Childhood Cancers |
Blastoma |
CREST 2 LOE |
Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial (C2LOE) |
Heart & Vascular |
Carotid Stenosis |
Improving Continuous Positive Airway |
Improving Continuous Positive Airway Pressure Adherence in Patients with Obstructive Sleep Apnea: Impact of Patient and Family Engagement (Improving CPAP Adherence |
Pulmonary |
Respiratory |
COG-ACNS0332 |
Efficacy of Carboplatin Administered Concomitantly with Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other than Average Risk Medulloblastoma/PNET Patients |
Childhood Cancers |
Blastoma |
ANT-010/Lilac |
A study to evaluate the effect of the experimental drug abelacimab relative to placebo in subjects with atrial fibrillation/flutter (AF) who are not treated with oral anticoagulants because they have been deemed by their responsible physicians or by their own decision to be unsuitable for currently available oral blood thinners. |
Heart & Vascular |
Atrial Fibrillation |
URCC 18007 |
A study see if Bupropion is effective for reducing cancer-related fatigue. You must have completed surgery, radiation and/or IV chemo at least 2 months prior to enrollment. |
Cancer |
All tumor types |
APEC14B1 EveryChild |
A Registry, Eligibility Screening, Biology and Outcome Study |
Childhood Cancers |
Registry |
V-Inception |
A randomized, controlled, multicenter, open-label trial comparing a hospital post-discharge care pathway involving aggressive LDL-C management that includes inclisiran with usual care versus usual care alone in patients with a recent acute coronary syndrome (VICTORION-INCEPTION) |
Heart & Vascular |
Lipid Management |
AALL1231 |
A Phase lll Randomized Trial Investigating Bortezomib (NSC#681239; IND# 58443) on a Modified Augmented BFM (ABFM) Backbone in Newly Diagnosed T-Lymphoblastic Leukemia (T-ALL) and T-Lymphoblastic Lymphoma (T-LLy) |
Childhood Cancers |
Leukemia |
COG-AREN03B2 |
Renal Tumors Classification, Biology, and Banking Study |
Childhood Cancers |
Tumor |
AALL08B1 |
Classification of Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) |
Childhood Cancers |
Leukemia |
COG-AHOD1331 |
A randomized Phase III Study of Brentuximab Vedotin (SGN-35, IND # 117117) for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma (cHL) in Children and Adolescents |
Childhood Cancers |
Lymphoma |
AALL1521 |
A Phase 2 study of the JAK1/JAK2 Inhibitor Ruxolitinib with Chemotherapy in Children with De Novo High-Risk CRLF2 Rearranged and/ or JAK Pathway-Mutant Acute Lymphoblastic Leukemia |
Childhood Cancers |
Leukemia |
COG-AEWS07B1 |
A Children's Oncology Group Protocol for Collecting and Banking Ewing Sarcoma Specimens |
Childhood Cancers |
Sarcoma |
Acoustic Diagnosis of Gastroesophageal Reflux Disease |
|
Baby/Child |
Reflux Disease |