Search for Current Clinical Trials

Study Name Description Trial Category Trial SubCategory
Integra-D The OPTIMIZER® INTEGRA CCM-D System is an investigational device system that combines device based therapy called Cardiac contractility modulation therapy (CCM) and implantable cardioverter-defibrillator (ICD) therapy into one device. Heart & Vascular Heart Failure
ANT-010/Lilac A study to evaluate the effect of the experimental drug abelacimab relative to placebo in subjects with atrial fibrillation/flutter (AF) who are not treated with oral anticoagulants because they have been deemed by their responsible physicians or by their own decision to be unsuitable for currently available oral blood thinners. Heart & Vascular Atrial Fibrillation
Evolve-MI An investigational study to learn whether regular healthcare, combined with early treatment with a cholesterol lowering drug called evolocumab (Repatha®) reduces heart attack, stroke, procedures to improve blood flow, and death, compared to regular healthcare alone. Heart & Vascular Lipid Management
ESsCAPE The main objective of the trial is to assess the efficacy and safety of the drug trimodulin as adjunctive treatment to standard of care compared to placebo plus standard of care in adults hospitalized with severe community-acquired pneumonia on invasive mechanical ventilation. Pulmonary Respiratory
Amgen Ocean(a) The primary objective of this study is to compare the effect of treatment with olpasiran, to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants with atherosclerotic cardiovascular disease (ASCVD) and elevated Lipoprotein(a). Patients must have a Lp(a) value of ≥ 200 nmol/L during screening. Heart & Vascular Cardiovascular Disease
Amplitude This research study is a way to find out if the Study Drug is safe and if it works to help people with APOL-1 mediated Chronic Kidney Disease. Nephrology Proteinuric Kidney Disease
Amulet Patients will have nonvalvular atrial fibrillation. This irregular beating of the heart leads to a slowing of the blood flow in the upper chambers of the heart. In the left upper chamber, there is a small pouch called the left atrial appendage (LAA). Slowing of blood, especially in the LAA, may cause blood clots to form. Blood clots can move from the LAA and travel to the brain, causing a stroke or transient ischemic attack (TIA), also called a mini-stroke. These blood clots can also travel to other parts of the body and block blood vessels. The Amulet device could be beneficial because it may lower the chance of a new blood clot forming and moving from the heart’s LAA to other parts of your body. Heart & Vascular Structural Heart Disease
Aveir DR The objective for this study is to confirm the safety and effectiveness of the Aveir LP (Leadless Pacemaker) System in a subject population indicated for a dual chamber pacemaker. Heart & Vascular Cardiac Arrhythmia
Bayer Oceanic AF The main purpose of this study is to collect more data about how well asundexian works to prevent stroke and systemic embolism and how safe it is compared to apixaban in people with atrial fibrillation and at high risk for stroke. The study treatment, asundexian, is a new type of anticoagulant currently under development to provide further treatment options. The way it works, it aims to further improve the standard of care with regard to the risk of bleeding. Heart & Vascular Atrial Fibrillation
Complete TAVR The purpose of this study is to determine whether restoring blood flow to all blocked or narrowed arteries via percutaneous coronary intervention (PCI) using coronary stents is better than treating the coronary artery disease (CAD) with medications in patients with CAD who had successful transcatheter aortic value replacement (TAVR) with a balloon expandable heart valve. The study will also compare measurements of hemodynamics (blood flow and blood pressure) that are taken during on-table procedures (TAVR and PCI) with those taken by echocardiography (heart ultrasound). Heart & Vascular Cardiovascular Disease
Iocyte Faraday STEMI drug The purpose of this study is to evaluate the efficacy and safety of the study drug vs placebo in subjects with an anterior ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). Heart & Vascular Heart Failure
Node X Participants must have participated in a prior study with the investigational drug etripamil (the NODE-301, NODE-302, or NODE-303 study). The study is being done to determine the safety of etripamil 70 mg for the treatment of multiple episodes of PSVT in an at-home setting. Heart & Vascular Cardiac Arrhythmia
PPP/PAN/PSR This study is a registry study. The purpose is to collect information over time about how Medtronic products are working and/or the outcome of the treatment. The registry will be used to support post-market surveillance activities and post-approval studies (e.g., to collect safety and performance information). In addition, it will be used to obtain clinical evidence for the development and improvement of medical devices, therapies, device guidelines, patient services/solutions and provide clinical data to support health economics and clinical outcomes research. The registry is not an experimental clinical study. Heart & Vascular Cardiac Arrhythmia
Rethink Reflux Registry The purpose of this study is to gather information about how the LINX device works over an extended period in people with GERD (gastric esophageal reflux disease). Surgery GERD (Gastro Esophageal Reflux Disease)
Amgen Registry Study of Lipoprotein(a) Levels in Patients With History of Atherosclerotic Cardiovascular Disease (ASCVD) Heart & Vascular Cardiovascular Disease
Arrhythmia Detection After Myocardial Infarction (AID-MI) This study will evaluate the use of an insertable cardiac monitor in patients following an acute myocardial infarction (heart attack) to determine if cardiac monitoring results in more rhythm-related findings that change management compared to standard of care post heart attack management in patients who do not receive the insertable cardiac monitor. Heart & Vascular Cardiac Arrhythmia
Change AF Pragmatic Randomized Clinical Trial of Early Dronedarone versus Usual Care to Change and Improve Outcomes in Persons with First-Detected Atrial Fibrillation (CHANGE AFib) Heart & Vascular Cardiac Arrhythmia
CREST 2 LOE Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial (C2LOE) Heart & Vascular Carotid Stenosis
Kintor Covid The objective for this study is to evaluate the safety and efficacy of the drug Proxalutamide in hospitalized adults diagnosed with COVID-19. Pulmonary Respiratory
Optimizer PAS The Impulse Dynamics OPTIMIZER Smart Pre-Market Application (PMA) clinical data confirmed that CCM therapy delivered with the Optimizer meaningfully improved health outcomes in patients with NYHA class III heart failure symptoms and left ventricular ejection fraction of 25-45%. CCM has shown significant improvements in quality of life measures, with an average improvement of >11 points in MLHWFQ incremental to the improvement of a randomized control group with no device. Six minute hall walk and functional class also showed improvements in the PMA data. The post-approval study (PAS) protocol has been designed to evaluate long term safety and efficacy of the OPTIMIZER Smart in a real-world setting. Heart & Vascular Heart Failure
Real AF Real-world Experience of Catheter Ablation for the Treatment of Symptomatic Paroxysmal and Persistent Atrial Fibrillation Using Novel Contact Force Technologies: REAL AF Registry Heart & Vascular Atrial Fibrillation
V-Inception A randomized, controlled, multicenter, open-label trial comparing a hospital post-discharge care pathway involving aggressive LDL-C management that includes inclisiran with usual care versus usual care alone in patients with a recent acute coronary syndrome (VICTORION-INCEPTION) Heart & Vascular Lipid Management
CanGaroo The objective of this study is to explore the subject clinical profiles, procedural details and post-implant outcomes of patients who receive either the CanGaroo ECM Envelope or no envelope at the time of initial implantation. Heart & Vascular Atrial Fibrillation
A011202 A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy Cancer Breast
A011801 The CompassHER2 Trials (Comprehensive Use of Pathologic Response Assessment to Optimize Therapy in HER2-Positive Breast Cancer) CompassHER2 Residual Disease (RD), a Double-Blinded, Phase III Randomized Trial of T-DM1 Compared With T-DM1 and Tucatinib Cancer Breast
A221805 Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase II to Phase III Study Cancer Gastrointestinal
ACCRU-BR-1801 A Phase II Trial of Abemaciclib and T-DM1 in Women and Men with HER2 positive Advanced or Metastatic Breast Cancer Who Progressed on Treatment with a Taxane, Trastuzumab and Pertuzumab Cancer Breast
EA2176 A Randomized Phase III Study of Immune Checkpoint Inhibition with Chemotherapy in Treatment-Naïve Metastatic Anal Cancer Patients Cancer Gastrointestinal
EA2187 A Phase 2 Study of Penvonedistat in Combination with Carboplatin and Paclitaxel in Advanced Intrahepatic Cholangiocarcinoma Cancer Gastrointestinal
NRG-GY009 Randomized Phase III, Two-Arm Trial of Paclitaxel/Carboplatin/Maintenance Letrozole Versus Letrozole Monotherapy in Patients with Stage II-IV, Primary Low-Grade Serous Carcinoma of the Ovary or Peritoneum Cancer Other